Module I
Molecular Biology and Bioinformatics: Introduction to
molecular biology- Nucleic acids-DNA-RNAProteins-Gene-Genome-Genetic
synthesis-Translation-Transcription-Protein synthesis-Chromosomes-Maps
and sequences-Human genome project.
Module II
Sequence alignment and database search: Pair-wise sequence
alignment- Substitution matrixes -PAM and BLOSSUM matrices,
Dot plots - Local and global alignment theory - Dynamic
programming methods -FASTA and BLAST algorithms - database
search using BLAST and FASTA - Similarity & distance
-Similarity scores - Weight matrices - Heuristic method
- Hidden Markov Models and their application in sequence
analysis
Module III
Phylogenetic trees: Introduction -Dendrogram construction
/ Molecular Phylogenetics / Tree definitions / Optimality
criteria / Distance matrix methods and maximum parsimony
/ Multiple sequence alignments- tree alignments, star
alignments, pattern in pair wise alignment / Genetic
algorithm
Module IV
DNA Micro-arrays and Gene Expression- Gene profiling-
DNA Microarray technology- Gene regulatory network-
Heuristic Algorithms for GRN- S-system model – Computational
methods for pathways and system biology- metabolic pathways-
genetic pathways- signaling pathways
Module V
Molecular Structure Prediction- RNA secondary structure
prediction-Protein Folding problems-Protein threading-
Protein structure analysis.
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1. Zhumar Ghosh and Bibekanand Mallick. Bioinformatics: Principles and Applications., Oxford University
Press; 1 edition , March 1, 2015
2. An introduction to Bioinformatics Algorithms 4th Ed: Neil James and Pavel A Pevzner, OUPress, 2014
3. Bioinformatics : Principles and Applications: Zhumur Ghosh, Bibekanand Mallick: OUPress. 2015
4. Building Bioinformatics Solutions: Concord Bessant, Darren Oakley, Ian Shadforth : OU press, 2014
5. Rastogi, S. C., Parag Rastogi, and Namita Mendiratta. Bioinformatics Methods and Applications:
Genomics Proteomics and Drug Discovery 4th Ed. PHI Learning Pvt. Ltd., 2013. |